Medical Specialties

Liver Diseases and Conditions that May Require a Pediatric Liver Transplant


Liver Transplants at Phoenix Children's Hospital

Most children who receive treatment for liver disease, including liver transplants, can lead productive lives with continued care.

The Pediatric Hepatology team at Phoenix Children’s Hospital provides comprehensive, multidisciplinary diagnoses and treatment options. These may include experimental and state-of-the-art procedures, to ensure that your child has the best opportunity to recover and thrive.

Types of Liver Disease and Conditions that May Require a Liver Transplant

There are several types of liver diseases and conditions that may require a transplant. The most common are:

1. Acute liver failure

2. Chronic liver diseases, including:

  • Alagille syndrome
  • Alpha-1-antitrypsin deficiency
  • Autoimmune hepatitis
  • Biliary atresia
  • Bile acid synthesis defect
  • Caroli’s syndrome and congenital hepatic fibrosis
  • Chronic hepatitis B and C
  • Cryptogenic cirrhosis
  • Cystic fibrosis liver disease
  • Drug-induced liver disease
  • Glycogen storage disease (GSD)
  • Parental nutrition associated liver disease (PNALD)
  • Progressive familial intrahepatic cholestasis (all types)
  • Sclerosing cholangitis
  • Tyrosinaemia type 1
  • Wilson's Disease

3. Liver tumors

  • Hepatoblastoma
  • Hepatocellular carcinoma
  • Hemangioendothioma
  • Unresectable benign liver tumors with disabling symptoms

4. Metabolic liver disease with life-threatening extra-hepatic complications

  • Crigler-Najjar syndrome
  • Hypercholesterolemia
  • Organic acidemias
  • Primary hyperoxaluria
  • Urea cycle defects

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