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Brian L. Appavu, MD

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Brian Appavu, MD


Main Hospital & Emergency Department
1919 E. Thomas Rd., Phoenix, Arizona 85016

About Brian L. Appavu, MD

Dr. Brian Appavu is an assistant professor of neurology and child health at the University of Arizona College of Medicine, and an ICU neurologist and epileptologist at Phoenix Children’s Hospital. He is one of an extremely select group of neurologists in the country board-certified in child neurology, epilepsy and neurosonology. Dr. Appavu champions the utilization of advanced physiologic techniques such as continuous electroencephalography and transcranial doppler ultrasound to provide advanced physiologic multimodal neuromonitoring and deliver the best neurologic care for critically ill children. Dr. Appavu is also passionate about pediatric neurocritical care education, providing monthly educational lectures to residents and fellows and running an advanced nursing neurocritical care course. Dr. Appavu was recently voted by the Barrow Neurological Institute residents as the 2018 Child Neurology Teacher of the Year. Dr. Appavu grew up in the suburbs of Chicago, IL and received his Bachelor of Science in biochemistry at the University of Illinois at Chicago. He received his medical degree at Medical College of Wisconsin and did his child neurology residency at the Barrow Neurological Institute at Phoenix Children’s Hospital. He completed a clinical neurophysiology fellowship at Columbia University Medical Center in New York. Dr. Appavu currently lives in Mesa, AZ with his wife Michelle who is an English professor and author, and their Portuguese water dog, Fawkes. Outside of work, Dr. Appavu enjoys hiking in the East Valley and jazz drumming.

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Education & Training

Medical School / Education

Medical College of Wisconsin


Barrow Neurological Institute at Phoenix Children's Hospital


Columbia University Medical Center, New York


Phoenix Children's Hospital

Professional Affiliations

Neurocritical Care Society, American Epilepsy Society, Child Neurology Society, American Academy of Neurology, American Society of Neuroimaging

Research & Publications

1. Appavu B, Riviello JJR. Electroencephalographic Patterns in Neurocritical Care – Pathologic Contributors or Epiphenomena? Neurocritical Care. 2018 Aug; 29(1):9-19. PMID: 28660340Appavu B

2. Fox J, Little R, Kerrigan JF, Obeid M. Seizures Induced by Exiting Water: A Unique Form of Reflex Epilepsy. Neurologist. 2017 Sep 22. PMID 28859025

3. Appavu B, Guido-Estrada N, Lindstrom K, Grebe T, Kerrigan JF, Troester M. Electroclinical Phenotypes and Outcomes in TBC1D24-Related Epilepsy. Epileptic Disorders. 2016 Aug 8. PMID: 27502353

4. Appavu B, Vanatta L, Condie J, Kerrigan J, Jarrar R. Ketogenic Diet Treatment for Pediatric Super-Refractory Status Epilepticus. Seizure. 2016 Oct;41:62-65. PMID: 27475280

5. Appavu B, Ashby D, Condie J. Manifestation of West Nile Encephalitis in Infancy. J Pediatric Infect Dis Soc. 2015 Dec;4(4):e166-8. PMID: 26501475

6. Appavu B, Mangum T, Obeid M. Glucose 1 Transporter Deficiency: a Treatable Cause of Epileptic Myoclonus. Pediatric Neurology. 2015 Oct;53(4):364-6. PMID: 26385057

7. Arsenieva D, Appavu BL, Mazock GH, Jeffery CJ. Crystal structure of phosphoglucose isomearse from Trypanosoma brucei complexed with glucose-6-phosphate at 1.6 Å resolution. Proteins. 2009 Jan;74(1):72-80.  PMID: 18561188WEBINARS

8. Appavu B (2018) Electroencephalographic Patterns in Neurocritical Care. Brain Matters Lecture Series. URL: